Afamin在妊娠期高血压疾病中的研究现状
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v3i2.4175
Abstract
妊娠期高血压疾病是妊娠期特有的并发症之一,目前发病机制尚不完全清楚,有研究表明,妊娠期高血压疾病患者常伴有脂代谢紊乱,脂质过氧化物或氧化应激可使内皮细胞分泌与炎症相关的炎性因子。而血浆Afamin已经被证实参与氧化应激过程。因此可以推测Afamin可能与妊娠期高血压疾病的发生发展相关。本文将对妊娠期高血压疾病的危害及Afamin的作用进行论述。
Keywords
妊娠期高血压疾病；Afamin；高血压疾病对母儿围生结局的影响
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[11] Nishio H,Dugaiczyk A.Complete structure of the human alphaalbumin gene, a new member of the serum albu min multigene family[J].Proc Natl Acad Sci U S A,1996,93(15):7557-7561.
[12] Jerkovic L, Voegele AF, Chwatal S, et al.Afamin is a novel human vitamin E-binding glycoprotein characterizat ion and in vitro expression[J].J Proteo me Res,2005,4(3):889-899.
[13] Dieplinger H,Dieplinger B.Afa min--A pleiotropic glycoprotein invo lved in various disease states[J].Clin Chim Acta,2015,446:105-110.
[14] 贾妍,曹正.维生素A、E检测及其在妊娠期妇女中应用进展[J].标记免疫分析与临床,2018,25(9):1406-1409.
[15] Voegele AF,Jerkovi L,Wellenzo hn B,et al.Characterization of the vitamin E- binding properties of hum an plasma afamin[J].Biochemistry,2002,41(49):14532-14538.
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[17] Zafar U,Khaliq S,Ahmad HU. Me tabolic syndrome：An update on diag nostic criteria,pathogenesis,and gene tic links[J]. Hormones(Athens),2018,17(3):299-313.
[18] Seeber B,Morandell E,Lunger F,etal.Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome[J].Reprod Biol Endocrinol,2014,12:88-94.
[19] Dieplinger B,Egger M,Gabriel C,etal. Analytical characterization and clinical evaluation of an enzyme-link ed immunosorbent assay for measureme nt of Afamin in human plasma[J]. Clin Chim Acta,2013,425:236-241.
[20] Hubalek M,Buchner H,Mörtl MG,e tal. The vitamin E-binding protein Afa min increases in maternal serum during pregnancy[J]. Clin Chim Acta,2014,434:41-47.
[21] Tramontana A,Dieplinger B,Sta ngl G,et al. First trimester serum afa min concentrations are associated with the development of preeclampsia and gestational diabetes mellitus in preg nant women[J].Clin Chim Acta,2018,476: 160-166.
[22] Köninger A,Enekwe A,Mach P,et al.Afamin:An early predictor of preec lampsia[J].Arch Gynecol Obstet,2018,298 (5)1009-1016.
[23] Tramontana A,Pablik E,Stangl G,et al. Combination of first trimester serum Afamin levels and three-dimen sional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in lowriskpregnancies [J].Placenta,2018,62:9-15.
[2] 吴祝如,古艺儿,陈宏霞.高龄女性妊娠期高血压疾病对妊娠结局的影响分析[J].中国妇幼健康研究,2017,28(6):739-741.
[3] 巴哈尔古丽·阿不来提,玛依拉·买买提,祖丽皮亚·依明,米娜瓦尔·艾麦提,海热姑丽·麦麦提尼牙孜.妊娠期高血压疾病的相关危险因素及其严重程度对母婴结局的影响[J].中国妇幼保健,2018,33(19):4380-4383.
[4] 邓瀚.妊娠期高血压危险因素及其对妊娠结局的影响[J].宁夏医科大学学报,2013,35(8):931-933.
[5] 赵晨丹.不同类型妊高症对妊娠结局的影响[J].中外健康文摘,2013,(21):107-108.
[6] 何伟红,贾沙利娅,董武.妊娠期高血压疾病对妊娠结局的影响探析[J].实用妇科内分泌杂志(电子版),2017,(7):10.
[7] 管中,李怀芳.氧化应激作用与妊娠期高血压疾病的关系[J].中华临床医师杂志(电子版),2014,8(16):3012-3015．
[8] 吴琳琳,雷琼,段冬梅.妊娠期代谢综合征:一个值得探讨的科学问题[J].中国实用妇科与产科杂志,2018,34(9):989-993．
[9] 高倩,刘兴会.妊娠与代谢综合征的关系[J].中华妇幼临床医学杂志(电子版),2015,11(5):652-655.
[10] Lichenstein HS,Lyons DE,Wurfel MM, etal. Afamin is a new member of the albumin,alpha-fetoprotein,and vitamin D-binding protein gene family [J]. J Biol Chem,1994,269(27)：18149-18154.
[11] Nishio H,Dugaiczyk A.Complete structure of the human alphaalbumin gene, a new member of the serum albu min multigene family[J].Proc Natl Acad Sci U S A,1996,93(15):7557-7561.
[12] Jerkovic L, Voegele AF, Chwatal S, et al.Afamin is a novel human vitamin E-binding glycoprotein characterizat ion and in vitro expression[J].J Proteo me Res,2005,4(3):889-899.
[13] Dieplinger H,Dieplinger B.Afa min--A pleiotropic glycoprotein invo lved in various disease states[J].Clin Chim Acta,2015,446:105-110.
[14] 贾妍,曹正.维生素A、E检测及其在妊娠期妇女中应用进展[J].标记免疫分析与临床,2018,25(9):1406-1409.
[15] Voegele AF,Jerkovi L,Wellenzo hn B,et al.Characterization of the vitamin E- binding properties of hum an plasma afamin[J].Biochemistry,2002,41(49):14532-14538.
[16] 尹士男,江华.代谢综合征的诊治进展[J].中华老年心脑血管病杂志,2018,20(11):1121-1123.
[17] Zafar U,Khaliq S,Ahmad HU. Me tabolic syndrome：An update on diag nostic criteria,pathogenesis,and gene tic links[J]. Hormones(Athens),2018,17(3):299-313.
[18] Seeber B,Morandell E,Lunger F,etal.Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome[J].Reprod Biol Endocrinol,2014,12:88-94.
[19] Dieplinger B,Egger M,Gabriel C,etal. Analytical characterization and clinical evaluation of an enzyme-link ed immunosorbent assay for measureme nt of Afamin in human plasma[J]. Clin Chim Acta,2013,425:236-241.
[20] Hubalek M,Buchner H,Mörtl MG,e tal. The vitamin E-binding protein Afa min increases in maternal serum during pregnancy[J]. Clin Chim Acta,2014,434:41-47.
[21] Tramontana A,Dieplinger B,Sta ngl G,et al. First trimester serum afa min concentrations are associated with the development of preeclampsia and gestational diabetes mellitus in preg nant women[J].Clin Chim Acta,2018,476: 160-166.
[22] Köninger A,Enekwe A,Mach P,et al.Afamin:An early predictor of preec lampsia[J].Arch Gynecol Obstet,2018,298 (5)1009-1016.
[23] Tramontana A,Pablik E,Stangl G,et al. Combination of first trimester serum Afamin levels and three-dimen sional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in lowriskpregnancies [J].Placenta,2018,62:9-15.
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